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Diagnosing Keratoconus

Diagnosing Keratoconus and Treatment Options

The goal of treatment for iLink® corneal cross-linking patients is to slow or halt the progression of keratoconus. For these patients, continued progression often results in loss of visual acuity or decreased tolerance to contact lens wear, caused by the ongoing changes in the cornea. This means early diagnosis is critical so that progressive keratoconus can be treated sooner.1

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Left untreated, 1 in 5 patients with progressive keratoconus may require a corneal transplant. More than half of these patients could need multiple transplants within 20 years. 2 3

[Pramanik] [Maharana]

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Identifying keratoconus patients

Appropriate patients who have been diagnosed with progressive keratoconus or corneal ectasia following refractive surgery may be candidates for iLink® corneal cross-linking.

  • Keratoconus is a bilateral, progressive corneal ectasia resulting in irregular astigmatism and loss of visual function, with onset in teenage years.
  • Corneal ectasia, a non-inflammatory condition marked by progressive corneal steepening and thinning, is a rare but serious complication of vision correction procedures.

What are the signs and symptoms of progressive keratoconus?

Early signs of keratoconus may include asymmetric refractive error, high or progressive astigmatism, or reduced best corrected visual acuity. The onset of keratoconus often occurs in the teenage years or early twenties but can start at any time.

Patient symptoms may include:

  • Constantly and regularly changing refractive errors
    Blurry vision
  • Increased light sensitivity
  • Difficulty driving at night
  • A halo around lights and ghosting (especially at night)
  • Eye strain
  • Headaches and general eye pain
  • Eye irritation, excessive eye rubbing

Keratoconus, especially in the early stages, can be difficult to diagnose, and all of the above symptoms could be associated with other eye problems.

What tools do I need to observe the signs of keratoconus?

Keratometry
  • Fleischer’s ring
  • Vogt’s striae
  • Apical scarring
Corneal topography or tomography
  • Topography and corneal thinning
Corneal OCT
  • Topography and corneal thinning

Topography Examples
Patient with Keratoconus.
Patient with Keratoconus.
Patient with normal astigmatism.
Patient with normal astigmatism.

Collaborating with surgeons and post-op care

iLink® corneal cross-linking provides the opportunity for collaborative care between optometrists and ophthalmologists.

Optometrists are an essential part of the ongoing medical care keratoconus patients receive after they have been treated with iLink® corneal cross-linking. It may be necessary for an optometrist to increase the frequency of a patient’s monitoring exams or fit them with contact lenses several times while their corneas stabilize.

Epithelial healing

Post-operative care management is up to the physician’s discretion. Although there is certainly some variation, corneal specialists will often see patients for the 1-day and 1-week visits and then, once the epithelium is intact, send them back to co-managing doctors for the remainder of the follow-up care. Patients should be monitored for resolution of epithelial defects.

Contact lens fitting

Scleral lenses or other vaulted designs are a good option for keratoconus patients as they do not rest on the corneal surface and avoid disrupting the epithelial healing. It is important to make patients aware that vision may change slightly during the first few months, and that the contact lens prescription may need to be updated.

For contact lens fitting purposes, one can expect that the corneal curvature may change after cross-linking, but not dramatically. It is not uncommon to notice an initial corneal steepening followed by flattening in the first months after an iLink® procedure. More frequent contact lens evaluations may be required in the first year after the procedure while the cornea stabilizes.

Clinical notes

“We report good visual results in patients who were fit in contact lenses after having undergone corneal cross-linking. Contact lens fits were as early as two weeks (soft lenses), but ranged depending on patient’s functioning needs and observed changes in corneal topography in the postoperative healing period. Gas permeable lenses were fit at the earliest 3 months postoperatively. Contact lens choice is a balance between patient’s needs and the lens able to achieve good comfort with optimal visual results.*”

-Clark Chang, OD, MS

*Results may vary

Resources for diagnosing keratoconus

IMPORTANT SAFETY INFORMATION

The most common side effects were red eye, haze, sensitivity to light, disruption of surface cells of the cornea, eye pain, eye irritation, watery eyes, swelling of eyelid, fine white lines in the cornea, reduced sharpness of vision, dry eye, and eye inflammation.

You should not have the EPIOXA™ corneal collagen cross-linking procedure if you have a known hypersensitivity to any ingredients in the product, have had cataract surgery and either did not receive an artificial lens in your eye or received a non-UV blocking artificial lens, have a history of herpetic keratitis, or are pregnant.

If you have any additional questions, please contact your doctor. Please see full Prescribing Information for EPIOXA HD and EPIOXA.

You are encouraged to report all side effects to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also call Glaukos at 1-888-404-1644.

APPROVED USES

The EPIOXA corneal collagen cross-linking procedure is performed by your eye doctor for the treatment of keratoconus. It does not require the removal of the corneal epithelium (outermost layer of the front of the eye). It consists of EPIOXA™ HD (riboflavin 5′-phosphate ophthalmic solution) 0.239% and EPIOXA™ (riboflavin 5′-phosphate ophthalmic solution) 0.177%, which are prescription eye drops used in combination with the O2n™ System and Boost Goggles®.

The EPIOXA corneal collagen cross-linking procedure is for the treatment of keratoconus in adults and pediatric patients 13 years of age and older.

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